Postoperative Chemoradiotherapy and Cetuximab for High-Risk Squamous Cell Carcinoma of the Head and Neck: Radiation Therapy Oncology Group RTOG-0234
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چکیده
منابع مشابه
Concurrent Chemoradiotherapy With Cisplatin Versus Cetuximab for Squamous Cell Carcinoma of the Head and Neck.
OBJECTIVES We previously reported inferior outcomes for locally advanced head and neck cancer treated with cetuximab (C225) versus cisplatin (CDDP). We now examine if this difference persists when accounting for HPV status and update outcomes on the entire cohort. MATERIALS AND METHODS From 3/106 to 4/1/08, 174 locally advanced head and neck cancer patients received definitive treatment with ...
متن کاملPostoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck.
BACKGROUND Despite the use of resection and postoperative radiotherapy, high-risk squamous-cell carcinoma of the head and neck frequently recurs in the original tumor bed. We tested the hypothesis that concurrent postoperative administration of cisplatin and radiotherapy would improve the rate of local and regional control. METHODS Between September 9, 1995, and April 28, 2000, 459 patients w...
متن کاملCetuximab therapy for head and neck squamous cell carcinoma: a systematic review of the data.
OBJECTIVE To review the current state of the data on the use of cetuximab in head and neck squamous cell carcinoma (HNSCC). DATA SOURCES The National Center for Biotechnology Information's PubMed and the Cochrane collection. REVIEW METHODS Search terms included cetuximab and head and neck cancer. These results were reviewed, and a second search was performed using limits: meta-analysis, ran...
متن کاملDensity of mast-cells and Microvessels Density in head and neck cutaneous Squamous Cell Carcinoma
Background and Aim: Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Mast cells may play a role in tumor progression and metastasis by increasing angiogenesis. The aim of this study was to investigate the role of mast cells by increasing angiogenesis in invasion of head and neck cutaneous squamous cell carcinoma. Materials and Methods: In this cross-sectional stud...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2014
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2013.53.9163